A broad area of research “Immunology : Acute infections can persistently compromise tissue-specific immunity.”

Dear Friends

As we can see now the term and challenges inside the biology is turning everyday but beside that scholar around the world engage in it. One of the classic work by Denise Morais, Timothy W Hand and his colleagues NIH bethesda Maryland USA, 2015. Most interesting in this paper is; Video of Work introduction, so please watch if you are interested in cell-cell interactions at the time of infection.


Infections have been proposed as initiating factors for inflammatory disorders; however, identifying associations between defined infectious agents and the initiation of chronic disease has remained elusive. Here, we report that a single acute infection can have dramatic and long-term consequences for tissue-specific immunity. Following clearance of Yersinia pseudotuberculosis, sustained inflammation and associated lymphatic leakage in the mesenteric adipose tissue deviates migratory dendritic cells to the adipose compartment, thereby preventing their accumulation in the mesenteric lymph node. As a consequence, canonical mucosal immune functions, including tolerance and protective immunity, are persistently compromised. Post-resolution of infection, signals derived from the microbiota maintain inflammatory mesentery remodeling and consequently, transient ablation of the microbiota restores mucosal immunity. Our results indicate that persistent disruption of communication between tissues and the immune system following clearance of an acute infection represents an inflection point beyond which tissue homeostasis and immunity is compromised for the long-term.

link for this paper: http://www.sciencedirect.com/science/article/pii/S0092867415010442

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